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Literature summary extracted from

  • Kamba, K.; Nagata, T.; Katahira, M.
    Catalytic analysis of APOBEC3G involving real-time NMR spectroscopy reveals nucleic acid determinants for deamination (2015), PLoS ONE, 10, e0124142 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.B9 cytosine in single-stranded DNA + H2O Homo sapiens the enzyme restricts the infectivity of viruses, such as HIV-1, by targeting CCC hotspots scattered through minus DNA strands, reverse-transcribed from genomic RNA uracil in single-stranded DNA + NH3
-
 ?
3.5.4.38 cytosine in single-stranded DNA + H2O Homo sapiens the enzyme restricts the infectivity of viruses, such as HIV-1, by targeting CCC hotspots scattered through minus DNA strands, reverse-transcribed from genomic RNA uracil in single-stranded DNA + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.B9 Homo sapiens Q9HC16
-
-
3.5.4.38 Homo sapiens Q9HC16
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.B9 5-methylcytosine in single-stranded DNA + H2O the enzyme exhibits low activity toward 5-methylcytosine n single-stranded DNA Homo sapiens ?
-
 ?
3.5.4.B9 cytosine in single-stranded DNA + H2O the enzyme restricts the infectivity of viruses, such as HIV-1, by targeting CCC hotspots scattered through minus DNA strands, reverse-transcribed from genomic RNA Homo sapiens uracil in single-stranded DNA + NH3
-
 ?
3.5.4.B9 cytosine in single-stranded DNA + H2O the enzyme preferentially converts cytidine to uridine at the third position of triplet cytosine (CCC) hotspots. The phosphate backbone is required for C-terminal domain of the enzyme to slide along the DNA strand and to exert the 3'->5' polarity. The higher the salt cncentration, the less prominent is the 3'->5' polarity Homo sapiens uracil in single-stranded DNA + NH3
-
 ?
3.5.4.38 5-methylcytosine in single-stranded DNA + H2O the enzyme exhibits low activity toward 5-methylcytosine n single-stranded DNA Homo sapiens ?
-
 ?
3.5.4.38 cytosine in single-stranded DNA + H2O the enzyme restricts the infectivity of viruses, such as HIV-1, by targeting CCC hotspots scattered through minus DNA strands, reverse-transcribed from genomic RNA Homo sapiens uracil in single-stranded DNA + NH3
-
 ?
3.5.4.38 cytosine in single-stranded DNA + H2O the enzyme preferentially converts cytidine to uridine at the third position of triplet cytosine (CCC) hotspots. The phosphate backbone is required for C-terminal domain of the enzyme to slide along the DNA strand and to exert the 3'->5' polarity. The higher the salt cncentration, the less prominent is the 3'->5' polarity Homo sapiens uracil in single-stranded DNA + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.B9 APOBEC3G
-
 Homo sapiens
3.5.4.38 APOBEC3G
-
 Homo sapiens